Upon analyzing the clinicopathological features of CRC patients, we observed that the expression levels of FIBG and TGF-β on serum-derived EVs were positively correlated with both clinical stages (Fig. 4B, E; Supplemental Tables 2 and 3, Supplemental Digital Content 1, http://links.lww.com/JS9/C460). The gene discussed is TGFB1; the disease is colorectal carcinoma.