We categorized CRC patients in the train and test sets into different subtypes based on pMMR/dMMR status, HER2 expression, and differentiation degree to evaluate the applicability of the diagnostic model across different CRC subtypes (Supplemental Fig 6, Supplemental Digital Content 7, http://links.lww.com/JS9/C466). Here, ERBB2 is linked to colorectal carcinoma.