Profound Accumulated Local Effects (ALE) analysis substantiated the superior predictive impact of FIBG, PDGF-β, and TGF-β in CRC prognosis, transcending the predictive power of CEA and CA19-9 (Supplemental Fig 3C, Supplemental Digital Content 4, http://links.lww.com/JS9/C463). The gene discussed is TGFB1; the disease is colorectal carcinoma.