The Shapley value analysis concurred, highlighting the substantial contribution of elevated PDGF-β (≥ 1.045), TGF-β (≥ 1.012), and FIBG (≥ 0.99) levels in discerning CRC from HC, corroborating the results of the importance analysis (Fig. 5D, E). This evidence concerns the gene PDGFB and colorectal carcinoma.