Current understanding suggests that lncRNAs play a crucial role in regulating numerous biological processes of CSCs by modulating the expression of vital transcription factors responsible for stem cell functions [23], lncRNA involvement in cancer stem cell function and epithelial-mesenchymal transitions [24], LncRNA PKMYT1AR promotes cancer stem cell maintenance via activating Wnt signaling pathway [25], LncRNA LINC01315 silencing modulates cancer stem cell properties and epithelial-to-mesenchymal transition [26]. The gene discussed is PKMYT1AR; the disease is cancer.