Nguyen et al. indicated that HHT and bortezomib an inhibitor of 20S proteasome) cooperatively can kill diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma cells through a process involving MCL-1 down-regulation, NOXA up-regulation and Bak activation [100]. This evidence concerns the gene BAK1 and diffuse large B-cell lymphoma.