For instance, HHT exerted a synergistic anti-leukaemia effect with venetoclax by decreasing mitochondrial membrane potential (MMP) (ΔΨm), reducing expression of Mcl-1 protein, inhibiting PI3k/Akt and MAPK/ERK pathways, activating p53 pathway, arresting cell cycle progression and inducing apoptosis in AML cells. Here, AKT1 is linked to acute myeloid leukemia.