Subsequent studies have focused on elucidating the efficacy of omacetaxine; these investigations revealed that OM can induce the rapid degradation (in less than 4 h) of several short-lived proteins crucial for cancer cell survival, such as Mcl-1, Cyclin D1, c-Myc, XIAP, β-Catenin, and the long isoform of cellular FLICE inhibitory protein (c-FLIPL), across various cell lines derived from CML, AML, CLL, and multiple myeloma patients [55]. Here, MCL1 is linked to acute myeloid leukemia.