Nguyen et al. indicated that HHT and bortezomib an inhibitor of 20S proteasome) cooperatively can kill diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma cells through a process involving MCL-1 down-regulation, NOXA up-regulation and Bak activation [100]. The gene discussed is PMAIP1; the disease is diffuse large B-cell lymphoma.