JAK2 and essential thrombocythemia: Essential thrombocythemia (ET) is a myeloproliferative neoplasm, a type of blood malignancy characterized by the overproduction of platelets in the bone marrow [111]; this disorder leads to an increased risk of blood clot formation; often associated with genetic mutations like JAK2, ET may present with symptoms related to clotting or may be asymptomatic [111].