Consistent with the significant effect of saccharin on Il1b and Cxcl2 expression, the infiltration of CD68+ macrophages and Ly6G+ neutrophils and their production of IL-1β in the psoriatic lesions were markedly reduced by saccharin treatment, particularly in autophagy deficiency (Fig. 6b). This evidence concerns the gene CD68 and hyperinsulinemic hypoglycemia, familial, 4.