In particular, autophagy protects against several inflammatory diseases, such as chronic rhinosinusitis (CRS) [29], gut inflammation in inflammatory bowel disease (IBD) [30], atherosclerotic progression [31], and liver injury [32], by regulating IL-1β production through degradation of the inflammasome components ASC and NLRP3 [33–35]. The gene discussed is PYCARD; the disease is inflammatory bowel disease.