To explore the direct role of autophagy in myeloid cells in the pathogenesis of psoriasis, we developed a model of psoriasis using Atg7fl/fl;LysM-Cre mice, which selectively exhibit a deficiency of the autophagy gene Atg7 in myeloid cells such as neutrophils and macrophages [45]. The gene discussed is ATG7; the disease is psoriasis.