GRIN2B encodes the GluN2B subunit of NMDA receptors (NMDARs), and its mutations have been implicated in various brain disorders, including ASD, developmental delay, intellectual disability, epileptic encephalopathy, attention-deficit/hyperactivity disorder, schizophrenia, obsessive-compulsive disorder [22–37]. This evidence concerns the gene GRIN2B and brain disorder.