Constitutive SHANK2 knockout [21, 22, 52, 54] and conditional SHANK2 deletion in certain cell type [55–57] brought divergent behavioral abnormalities in social, repetitive, locomotor, anxiety and hyperactivity domains in mouse models, hinting the distinct role of SHANK2 in different neuron subtypes and brain areas that contributes to diverse brain functions [49]. The gene discussed is SHANK2; the disease is Anxiety.