Deciphering the intrinsic properties and functionality of Aldh1a1 in dopamine, large amount of studies have correlated reduction of Aldh1a1 expression or substantial loss of Aldh1a1 positive DA neurons selectively in SN to etiopathogenesis of PD, indicating this distinct neuron subpopulation as a crucial role in motor skill learning [37, 61, 62]. Here, ALDH1A1 is linked to Parkinson disease.