The most common TEAEs (any grade) were thrombocytopenia (65.3 %), anemia (63.2 %), nausea (56.8 %), fatigue (53.7 %), leukopenia (46.3 %), neutropenia (34.7 %), vomiting (34.7 %), and alanine aminotransferase (ALT) increased (31.6 %) (Table 3). This evidence concerns the gene GPT and Decreased total leukocyte count.