Peri-procedural TEAEs that occurred in 20 % or more of the patients were anemia (56.0 %), thrombocytopenia (50.5 %), nausea (41.8 %), international normalized ratio (INR) increased (30.8 %), vomiting (29.7 %), prolonged activated partial thromboplastin time (PTT) (28.6 %), fatigue (23.1 %), aspartate aminotransferase (AST) increased (23.1 %), and ALT increased (22.0 %) (Table 4). This evidence concerns the gene GPT and anemia.