Next, the expression levels of five key genes were found to correlate with the expression levels of several moyamoya disease-related genes (Fig. 5B), with H19 positively correlating with ADARB2 (Pearson r = 0.628) and STK3 negatively correlating with ISG15 (Pearson r = − 0.556). The gene discussed is ADARB2; the disease is Moyamoya disease.