In ovarian cancer, CXCR4 was detected among 681 hypo methylated-upregulated genes while PTEN, and FOXO-1 were mentioned among the hypermethylated repressed genes [65] and in vascular smooth muscle cell (SMC), vascular injury increased PTEN/AKT signalling through CXCL12- HIF-1alpha [66]. This evidence concerns the gene AKT1 and ovarian cancer.