Cervical cancer, malignant pleural mesothelioma, ovarian cancer and renal cell carcinoma secrete CXCL12, which recruits CXCR4 expressing Tregs [22] impaired by the specific CXCR4 antagonist AMD3100 [23–26]. This evidence concerns the gene CXCR4 and hereditary clear cell renal cell carcinoma.