The remarked positive correlation between serum SIRT1 and IGFBP3 among obese CRC patients could be explained on the basis that an interaction exists between SIRT1, IGFBP3, and IGF-1/phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signal transduction and seems to play pleiotropic effects in malignancy78. This evidence concerns the gene AKT1 and colorectal carcinoma.