MEG3 and colorectal carcinoma: To further elucidate the possible role of MEG3 rs941576 SNP in predisposing CRC, the mechanistic impact of MEG3 rs941576 SNP on MEG3 expression was contemplated; however, we failed to find a significant association of rs941576 genotypes with serum MEG3 expression levels in the recruited CRC patients in the codominant, dominant, and recessive models (P > 0.05) (Fig. 2).