Interestingly, the AUCs for MEG3, miR-27a, IGF1, and IGFBP3 were improved and recorded at 0.717, 0.975, 0.898, and 0.929, respectively, while were comparable to that for the whole CRC group for miR-181a and SIRT1 (AUC = 0.915 and 0.818, respectively) (Table 7). Here, SIRT1 is linked to colorectal carcinoma.