Despite the inconsistent results about miR-181a and SIRT1 in cancer and their dual functions, as promoters and inhibitors, in certain tumors72–76, the results inferred from the current study mirror similar reports of heightened levels of miR-181a and SIRT1 in CRC tumor tissue and cell lines or serum72,74,77. The gene discussed is SIRT1; the disease is neoplasm.