SIRT1 and colorectal carcinoma: ROC curve analysis unveiled serum miR-181a as an excellent discriminator (AUC = 0.9235) and miR-27a, SIRT1, IGF1, and IGFBP3 levels as promising discriminators (AUC = 0.8487, 0.8036, 0.7452, and 0.8251), whereas serum MEG3 levels was only a significant discriminator (AUC = 0.646) between CRC patients and healthy controls (Fig. 4).