Cognitively unimpaired, mild cognitive impairment and Alzheimer’s disease participants (N = 132, Supplementary Table 1) underwent structural and resting-state functional MRI and Aβ (18F-NAV4694)-, tau (18F-MK-6240)- and microglial activation (11C-PBR28)-PET. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.