In conclusion, the findings further our understanding of the role of GlycA in lung function, asthma, and COPD susceptibility, reveal the prominent genetic-based role and potential shared mechanisms by identifying significant instrumental effects and shared genetic components including IL6R, UBA7, CTSB, SOX7, and TOMM40-APOE-APOC1, all of which may provide insights into biological mechanisms of lung function, asthma, and COPD. This evidence concerns the gene APOE and chronic obstructive pulmonary disease.