Additionally, locus chr8p23.1 was also identified to be shared across GlycA and multiple lung function parameters/respiratory diseases, but TWAS only validate its association with both GlycA and COPD at SOX7 suggesting Wnt/β-catenin signaling pathway through regulating cell proliferation, differentiation, tissue repair and extracellular matrix production in the shared pathology of both GlycA and COPD. The gene discussed is SOX7; the disease is chronic obstructive pulmonary disease.