ESRRA and osteoporosis: Moreover, although we observed adipocyte ESRRA inhibition leads to a significantly augmentation of osteoprogenitors associated with improved type H vessel formation in adipocyte-rich bone marrow, this study is limited without using elderly OVX mice or aged female mice at over 18 months of age to mirror bone turnover in elderly postmenopausal women and preclinical testing of potential therapies for osteoporosis.