Immune-related pathways (e.g. ‘IL-6 signalling’ and ‘Complement System’) were significantly overrepresented in DE genes and had increased activation (all p < 0.0001) including ‘Agranulocyte Adhesion and Diapedesis’ (p = 0.005), confirming that previously reported changes in schizophrenia compared to controls10 were driven by the HI-SCZ subgroup. This evidence concerns the gene IL6 and schizophrenia.