In our previous study comparing the SEZ transcriptome between controls and schizophrenia, five ECM related genes were also increased in schizophrenia compared to controls (COL4A1, COL4A2, COL3A1, TGFBI, TIMP1)10, and this study demonstrates those changes were mainly occurring in the HI-SCZ subgroup. Here, COL4A1 is linked to schizophrenia.