The remaining variant (p.C401LfsX15) involved CASP10 catalytic domain (C401 being the central residue of the QACQG catalytic site) and had been previously found in two patients with multi-organ autoimmunity and infections, and in one of these two cases resistance to FAS-mediated apoptosis was described [24, 29]. This evidence concerns the gene CASP10 and Autoimmunity.