FAS and autoimmune lymphoproliferative syndrome: Such plot is furtherly complicated by reports of other variants (homozygous and heterozygous p.V410I, heterozygous p.Y446C, p.P228L and p.I522L) which have inconstantly been associated with ALPS [24, 27] or that may even have a protective effect on the development of ALPS in subjects with a concurrent FAS mutation [23].