Among the others, p.K99E was reported in one patient and considered likely benign [9], p.P501L co-occurred with a heterozygous FAS mutation [25], while a 13.4 kb intragenic CASP10 deletion was reported in a patient whose phenotype was completely different from classical ALPS [26]. The gene discussed is CASP10; the disease is autoimmune lymphoproliferative syndrome.