Inhibition of USP7 attenuated IRI-AKI by inhibiting ferroptosis through decreasing the ubiquitination of TRIM27-mediated TANK-binding kinase 1 (TBK1) and promoting DNA methyltransferase 1 (DNMT1)-mediated methylation of FMRP translational regulator 1 (FMR1) [45]. Here, DNMT1 is linked to acute kidney injury.