Compared with sh-NC + oe-NC group, sh-NAC1 + oe-NC group showed a significant reduction in the maximum tumor volume and tumor nodules in the liver tissue of HBV transgenic mice; compared with sh-NAC1 + oe-NC group, sh-NAC1 + oe-LDHA group showed a significant increase in the maximum tumor volume and tumor nodules in the liver tissue of HBV transgenic mice (Fig. 7G). Here, LDHA is linked to neoplasm.