We extracted 75 enriched genes from 3 pathways and intersecting with 169 prognostic-related genes from TCGA database resulted in 15 genes closely associated with the HBV infection-induced liver cirrhosis and HCC, namely TOP2A, CDC20, AURKA, IGFBP3, DAXX, RPS19, TRIM28, PPARGC1A, TRAF2, TUBB, RHBDF2, FGFR4, ENG, NAC1, and FATE1. The gene discussed is RPS19; the disease is hepatocellular carcinoma.