We extracted 75 enriched genes from 3 pathways and intersecting with 169 prognostic-related genes from TCGA database resulted in 15 genes closely associated with the HBV infection-induced liver cirrhosis and HCC, namely TOP2A, CDC20, AURKA, IGFBP3, DAXX, RPS19, TRIM28, PPARGC1A, TRAF2, TUBB, RHBDF2, FGFR4, ENG, NAC1, and FATE1. This evidence concerns the gene TOP2A and hepatocellular carcinoma.