We analyzed EPB41L4A-AS1 expression levels in different brain regions of patients with AD and normal controls using an AD dataset (GSE5281), and found that patients with AD showed significantly lower EPB41L4A-AS1 expression than that in normal controls (Fig. 1a), especially in the hippocampus (HIP), medial temporal gyrus (MTG), posterior cingulate (PC), and superior frontal gyru (SFG) (Fig. 1b–g). Here, EPB41L4A is linked to Alzheimer disease.