Recent advances have demonstrated that the adoptive transfer of CAR-T cells, specifically engineered to target the urokinase plasminogen activator receptor (uPAR)—a surface protein upregulated on some senescent cells—not only prolonged survival in a mouse model of lung adenocarcinoma undergoing oncotherapy-induced senescence, but also mitigated liver fibrosis triggered by chemical or dietary factors [28]. Here, PLAUR is linked to lung adenocarcinoma.