For example, intraperitoneal administration of amodiaquine (AQ), which binds to the ligand-binding domain of Nurr1 with high affinity, suppressed microglial activation in the peri-hematoma area, inhibited gene expression of inflammatory mediators, ameliorated CST injury and improved motor dysfunction after ICH in mice [19,20]. Here, NR4A2 is linked to hematoma.