IFNγ ELISpot responses at the community-acquired infection visit were significantly higher than those measured at the immediately preceding visit, in all peptide pools (S1: median 409 [IQR 251–804] vs 141 [119–304], p=0·0098; S2: 467 [159–783] vs 211 [89–320], p=0·0039; M: 116 [43–471] vs 48 [29–89], p=0·0020; NP: 436 [336–1348] vs 109 [51–159], p=0·0020; CD4: 573 [272–1215] vs 215 [108–344], p=0·0029; CD8: 108 [33–211] vs 44 [29–67], p=0·026; ORF3: 177 [48–528] vs 64 [28–99], p=0·0098; ORF8: 81 [20–167] vs 24 [4–39], p=0·0020), except ORF-6, ORF-7, and ORF-10 (figure 4C). Here, CD4 is linked to infection.