DE analysis (Figure 7A) discovered candidates such as microtubule-associated protein RP/EB family member 3, adhesion G protein-coupled receptor F5 (MAPRE3, ADGRF5, specific to RO) and glycoprotein nonmetastatic melanoma protein B (GPNMB upregulated in chRCC) (Figures 7B, 7C, and S7C). Here, CALR is linked to chromophobe renal cell carcinoma.