TKT and cancer: Several enzymes in the oxidative (e.g., G6PD) as well as non-oxidative (e.g., TALDO1, TKT) phases of pentose phosphate pathway was highly expressed in pRCC type 1 (Figures 5D, S5C, and S5D), associated with increased demand for ribonucleotides in the rapidly proliferating cancer cells.66