In addition, the RNA binding protein and N6-methyladenosine reader IGF2BP3 showed a significantly higher mRNA expression in non-ccRCC high-wGII samples (Figure 1G), and upregulation trend noted in protein expression was validated by immunohistochemistry (IHC) (Figure S1G). This evidence concerns the gene IGF2BP3 and nonpapillary renal cell carcinoma.