Notable non-ccRCC subtype-specific events include: the signature chromosomal losses and TP53 mutations in chRCC (3/3 cases), chr7/17 gain (8/13 cases), and MET mutations (3/13 cases) in pRCC, TSC gene mutations in ESCRCC (2/2 cases) and AML tumors (2/2 cases), and the TFE3 gene fusion in a TRCC case. The gene discussed is TFE3; the disease is acute myeloid leukemia.