Next, evaluating the expression of glycosylation enzymes associated with glycosylation alterations, we noted high levels of glycotransferases (e.g., MGAT1, FUT11) and low levels of glycohydrolases (e.g., GLB1, FUCA1, FUCA2, HEXA, HEXB) in ccRCC versus NATs and other RCC subtypes, at both RNA and protein levels69 (Figure S4G). Here, GLB1 is linked to nonpapillary renal cell carcinoma.