Low abundance of ALDH2 is known to lead accumulation of toxic acetaldehyde and lipid aldehydes as well as to decrease in lipolysis within the mature adipocytes of SAT; however, these reported differences could be explained by the difference of proteomics analysis employed, more recent in the case of Benabdelkamel et al. [25] and the significative differences in BMI of population with obesity from both studies [24, 25]. This evidence concerns the gene ALDH2 and obesity due to melanocortin 4 receptor deficiency.