Treatment of CFPAC human pancreatic cancer cells in vitro with these [177Lu]Lu-DOTA-GIP-SPNs (0.37–11.1 MBq/mL) combined with PTT by irradiation with a 808 nm laser (1 W cm−2, 5 min) reduced cell viability in a concentration-dependent manner to as low as 4.4%, while treatment with the highest concentration of [177Lu]Lu-DOTA-GIP-SPNs, only reduced cell viability to 34%. The gene discussed is GIP; the disease is familial pancreatic carcinoma.