CD274 and neoplasm: In this study, we were interested to investigate if treatment of the primary tumour with the NPD incorporating PEG2K-pGlu(DOTA-[90Y]Y)8-LA4-AuNPs would cause an immune-mediated abscopal effect on the distant tumour, particularly with co-administration of anti-Programmed Cell Death Ligand-1 (anti-PD-L1) checkpoint antibodies.