Intratumoural (i.t.)injection of these [177Lu]Lu2O3-DOTA-HYNIC-iPSMA or [177Lu]Lu2O3-DOTA-HYNIC-iFAP NPs in mice with s.c. HCT116 human colon cancer xenografts resulted in very high tumor uptake that was retained up to 96 h p.i. (77–84% ID/g) with minimal uptake in the liver (~ 1% ID/g) or spleen (< 0.5% ID/g). This evidence concerns the gene MBTPS2 and neoplasm.