On multivariate analysis, age, presence of DM or hypertension, and recessive genetic models of FURIN and IFNL4 were the independent risk factors for severe and critical illness (ORs (CI) 1.054 (1.02–1.088), 4.162 (1.596–10.85), 3.724 (1.337–10.374), 3.041 (1.139–8.123), and 3.420 (1.152–10.153), respectively. The gene discussed is IFNL4; the disease is hypertensive disorder.