On multivariate analysis, age, presence of DM or hypertension, and recessive genetic models of FURIN and IFNL4 were the independent risk factors for severe and critical illness (ORs (CI) 1.054 (1.02–1.088), 4.162 (1.596–10.85), 3.724 (1.337–10.374), 3.041 (1.139–8.123), and 3.420 (1.152–10.153), respectively. This evidence concerns the gene IFNL4 and diabetes mellitus.