On multivariate analysis, age, presence of DM or hypertension, and recessive genetic models of FURIN and IFNL4 were the independent risk factors for severe and critical illness (ORs (CI) 1.054 (1.02–1.088), 4.162 (1.596–10.85), 3.724 (1.337–10.374), 3.041 (1.139–8.123), and 3.420 (1.152–10.153), respectively. Here, IFNL4 is linked to Hypertension.