BMAL1 and neoplasm: Furthermore, when BMAL1-depleted HL60 cells were injected into BALB/c mice, it provided further evidence to support the involvement of BMAL1 in promoting tumor growth in vivo. Previous reports have also demonstrated the essential role of BMAL1 in leukemia cell growth without causing hematopoietic defects, suggesting that BMAL1 genes could be effective therapeutic targets in AML (Puram et al. 2016).