Converging AD findings suggest that the aggregation of pathological tau is followed by a complex cascade of downstream neurodegeneration or neuronal injury and contributions to cognitive decline (Boccalini et al., 2024; Boxer & Sperling, 2023; Kaufman et al., 2016; La Joie et al., 2020; Ossenkoppele et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.