Reprogramming of neutrophils for the phenotypic switching to PMN‐MDSCs occurs due to G‐CSF, GM‐CSF, TGF‐β, TNF‐α, IFN‐γ, IFN‐β, and IL‐17 overexpressed by the tumor cells, cancer‐associated fibroblasts, and TAMs.21 The gene discussed is TNF; the disease is cancer.