Hypoxia also triggers the secretion of CXCL8 in TAMs that activates the C‐X‐C Motif Chemokine Receptor 1/2 (CXCR1/2) on the plasma membrane of gastric cancer cells further activating the Janus kinase 1/Signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway. The gene discussed is CXCL8; the disease is gastric cancer.