Finally, these HLA variant-associated phenotypes were categorized into distinct patterns according to the HLA class of their corresponding variants: (1) only class I HLA variations (arthritis, AS, T-CHO, HB, HCT and the VC/HT ratio); (2) only class II HLA variations (drug allergy, asthma, and HDL); (3) both class I and class II HLA variations (TG, creatinine, albumin, SGOT, AFP, RBC, WBC, and platelet) (Supplementary figure 2C). This evidence concerns the gene AFP and arthritic joint disease.