In the light of our recent study showing that VEGFR2 blockade hampered breast cancer cell proliferation via enhancing mitochondria biogenesis [19], herein, we aimed to investigate whether the expression of VEGFR2 correlates with the grading of gliomas and if VEGFR2 blockade-regulated mitochondria biogenesis operates as a general anti-cancer mechanism using the glioblastoma cells U38 and U87. The gene discussed is KDR; the disease is breast carcinoma.