This was evidenced by proteomic data that mitochondrial biogenesis/function-related proteins, e.g., PGS1, DARS2, TXN2, DHODH, NDUFS8 et al., were upregulated in U87 glioblastoma cells upon VEGFR2 inhibition by Ki8751 (Fig. 2). Here, DARS2 is linked to glioblastoma.