This was evidenced by proteomic data that mitochondrial biogenesis/function-related proteins, e.g., PGS1, DARS2, TXN2, DHODH, NDUFS8 et al., were upregulated in U87 glioblastoma cells upon VEGFR2 inhibition by Ki8751 (Fig. 2). This evidence concerns the gene TXN2 and glioblastoma.