Recent studies also showed associations between LC-I and early tau accumulation in the entorhinal cortex [49], and between NBM volume and neurodegeneration in the entorhinal and perirhinal cortices [50], which argues in favour of an early involvement of these subcortical structures in AD pathogenesis, particularly as a potential starting point for the spread of proteinopathies. Here, MAPT is linked to proteostasis deficiencies.