Furthermore, patients with SSc and anti-SSA indicated that anti-SSA-positive SSc without SS was strongly associated with dcSSc when compared to that in patients with SS (OR = 6.45; 95% CI, 1.23-32.60; P = 0.024).<h4>Conclusions</h4>Anti-SSA positivity increases the risk of organ involvement, such as ILD, in patients with SSc. This evidence concerns the gene CALR and systemic sclerosis.