IL-3 levels are also increased in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients, and its association with human relapsing-remitting MS (RRMS) exacerbates spinal cord inflammation, demyelination, and clinical severity in experimental autoimmune encephalomyelitis (EAE) [31]. This evidence concerns the gene IL3 and relapsing-remitting multiple sclerosis.