Nrf2 has been shown to be involved in protection of cells from calcium-induced oxidative stress in degenerative nerves [55] and stressed lens cells [56], and is also associated with the regulation of mitochondrial homeostasis [57] and Ca2+-related epithelial–mesenchymal transition in hepatocellular carcinoma cells [58]. The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.