After knocking down the expression of Piezo1, HUVECs in the HG group also showed lower MDA production and higher SOD activity when stimulated by Yoda1 (Fig. 5H, I), thereby indicating that Piezo1 is involved in the reduction of antioxidant capacity and increase in the oxidative capacity of endothelial cells with hyperglycemia. This evidence concerns the gene SOD1 and Hyperglycemia.