HDAC2 and dysplastic oral keratinocyte: Chang et al. [41] found positive HDAC2 nuclear staining was detected in 80/93 OSCC samples and 11/20 oral epithelial dysplasia (OED) samples and the labeling index for HDAC2 staining increased substantially from OED (25.8 ± 26.5%) to OSCCs (59.8 ± 28.5%) (p < 0.001) [41].