Furthermore, HDAC6 has been implicated in autophagy and served as a critical regulator of cytoprotective response, bridging the connection between autophagy and Mubiquitin-proteasome system, mediating regulation between endoplasmic reticulum (ER) stress, autophagy and conferring chemoresistance in HNSCC [74]. Here, HDAC6 is linked to head and neck squamous cell carcinoma.