HMGB1 and Hepatic fibrosis: Pathways related to tissue fibrosis included the wound healing signaling pathway, phagosome formation, hepatic fibrosis signaling pathway, IL-17 signaling pathway, pulmonary healing signaling pathway, differential regulation of cytokine production in macrophages, VDR/RXR activation, LPS/IL-1 mediated inhibition of RXR function, HMGB1 signaling, and IL-6 signaling pathway (Fig. 7B, red bars).