Hu et al. reported that chronic variable mild stress (CVMS) induced anxiety- and depression-like behaviors and increased neuronal excitability of ovBNSTCRF neurons and that intra-ovBNST injection of R121919, a CRFR1-selective antagonist, ameliorated the CVMS-induced anxiety- and depression-like behaviors [9]. Here, CRHR1 is linked to Anxiety.