Moreover, the expression of lncRNA HULC, regulated by miR-6825-5p, miR-6845-5p, and miR-6886-3p, elevates the deubiquitination effect of USP22 on SIRT1, making hepatocellular carcinoma (HCC) cells resistant to oxaliplatin and inducing protective autophagy in HCC cells [74]. This evidence concerns the gene SIRT1 and hepatocellular carcinoma.