Leveraging sepsis datasets from the GEO public database(GSE28750, GSE54514, GSE67652, GSE69528, GSE95233), a transcriptional-level meta-analysis was performed on COX7B and NDUFA4. This analysis revealed that both COX7B and NDUFA4 exhibit higher expression levels in the sepsis group compared to the normal control group, with this difference being remarkably different (P < 0.01) (Fig. 6A-B), indicating their potential significance in sepsis research. This evidence concerns the gene COX7B and Sepsis.