The results showed that compared with normal, CENPE was expressed in bladder uroepithelial carcinoma (BLAC)), breast invasive carcinoma (BRCA), rectal adenocarcinoma (READ), colon adenocarcinoma (COAD), lung squamous cell carcinoma (LUSC), head and neck squamous cell carcinoma (HNSC), esophageal carcinoma (ESCA), stomach adenocarcinoma (STAD) and other tumors with significantly increased expression. The gene discussed is CENPE; the disease is colon adenocarcinoma.