Univariate logistic regression analysis demonstrated significant associations between renal non-recovery and several factors, including age, sepsis severity, serum lactate level, SCr at enrollment, AKI stage, as well as urinary levels of [TIMP-2]•[IGFBP7] and CCL14 (all with P < 0.05). The gene discussed is IGFBP7; the disease is acute kidney injury.