In contrast to studies on viral and parasitic infections, a higher frequency of CD27‒ aMBCs along with CD8+ T cells was associated with better survival and good prognostic markers in tumor tissues of patients with ovarian and hepatocellular carcinoma [38, 40] as well as in the TDLNs of patients with head and neck squamous cell carcinoma (HNSCC) [53]. Here, CD27 is linked to head and neck squamous cell carcinoma.