Using a single-cell multimodal and two single-cell RNA-seq datasets for fine mapping of risk SNPs, we prioritized KIF5C, EPC2, TMEFF2, HLA-E, ATAT1, TUBB, ARID1B, and RUNX1 as potential risk genes with strong evidence of involvement in the early stages of AD. Here, ARID1B is linked to Alzheimer disease.