The t(8;21)(q22;q22) translocation resulting in the RUNX1-ETO (also called AML1-ETO or RUNX1-RUNX1T1) rearrangement is one of the most common genetic alterations in acute myeloid leukemia (AML), accounting for 5–10% of AML cases [1–3]. Here, RUNX1 is linked to acute myeloid leukemia.