There was no statistically significant association between ASC (β = 0.28; p = 0.65), caspase-1 (β = 0.16; p = 0.57) and IL-1β (β = − 0.27; p = 0.27) in mTBI patients with obese BMI compared to mTBI patients with non-obese BMI. This evidence concerns the gene CASP1 and concussion.