The logistic regression model to predict QOLIBRI-OS at 6-months had an R2 = 0.28 and included hypertension, hyperlipidemia, and the interaction term of severely obese BMI and IL-1β (p < 0.001) as a significant predictor, such that reporting hypertension, hyperlipidemia or having higher IL-1β in the severely obese group reduced QOLIBRI-OS scores at 6-months. The gene discussed is IL1B; the disease is Hypertension.