CFL1 and Parkinson disease: Among other proteins structurally altered upon the addition of aSyn fibrils, we also identified the amyloidogenic protein gelsolin (GSN), a component of PD-associated intraneuronal inclusions of which aggregated aSyn is a major component (Welander et al, 2011), as well as the actin-binding protein cofilin-1 (CFL1), which is known to co-aggregate with aSyn fibrils and is implicated in pathogenicity in PD (Tan et al, 2022; Yan et al, 2022).