In addition, we identified structural changes in several proteins, such as AGRN, SYNJ1, MAP1B, and YWHAZ, which have been implicated in PD based on disease-gene associations mined from literature, and in peroxiredoxin-1 (PRDX1), which has been linked to neurodegenerative processes (Hallacli et al, 2022; Szeliga, 2020). Here, SYNJ1 is linked to Parkinson disease.