In support of this notion, the GnRH pulse generator activity was suppressed by 2DG-induced glucoprivation or insulin-induced hypoglycemia in female goats because the intravenous infusion of 2DG or insulin prolonged the interval of MUA volleys as an indicator of GnRH pulse generator activity in OVX goats treated with luteal phase levels of E228. This evidence concerns the gene GNRH1 and Hypoglycemia.