These studies showed a relationship between COVID-19 severity and the VDR polymorphisms of FokI (rs2228570, C > T), TaqI (rs731236, A > G), BsmI (rs1544410, G > A) and CYP2R1 gene (rs10741657, G > A)8,18,21,23–25. This evidence concerns the gene CYP2R1 and COVID-19.