GPT and cancer: In addition to the absence of changes in body weight, mice treated with mTZ3-LNP and GCV exhibited neither tissue damage to the organs nor significant changes in the serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and creatinine, highlighting the safety of mTZ3-LNP-mediated lytic induction therapy in preclinical models of EBV-associated cancer (Supplementary Fig. 11b and 14a–c).