CD8A and type 1 diabetes mellitus: In contrast, both AAb+ (median 81.1) and recent T1D (median 55.7) had markedly higher aggregation of CD8+ T cells within islets relative to both control and prolonged T1D groups (Kruskal–Wallis p = 5.68e−3) (Fig. 7e–i), recapitulating the expected dynamics of CD8+ T cells aggregation with islets during the natural history of T1D29–32.